Status:
UNKNOWN
Translational Approaches to Septic Cardiomyopathy
Lead Sponsor:
Samuel Brown
Collaborating Sponsors:
Euan Ashley
Conditions:
Cardiomyopathies
Sepsis
Eligibility:
All Genders
18+ years
Brief Summary
This translational study will assess the association between septic cardiomyopathy (measured via left ventricular global longitudinal strain) and (a) inflammatory cytokine profiles, and (b) the behavi...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA
- At least 18 years of age Admitted to the ICU
- SEPSIS PATIENTS:
- Sepsis patients must have:
- Suspected or confirmed infection AND
- Organ dysfunction as defined by a SOFA \>= 2 above baseline (if no baseline data available, SOFA assumed to be 0)
- OR
- SEPTIC SHOCK PATIENTS:
- AFTER INFUSION OF 20ML/KG CRYSTALLOID OR EQUIVALENT, septic shock patients must have:
- Suspected or confirmed infection AND
- Lactate \> 2 mmol/L AND
- Receiving vasopressors
- EXCLUSION CRITERIA Known pregnancy Primary diagnosis of acute coronary syndrome Known preexisting heart disease Known severe valvular disease (regurgitation or stenosis)
- Major cardiac dysrhythmia such as:
- Ventricular tachycardia (V-tach)
- Ventricular Fibrillation (V-fib)
- Third degree heart block (complete hear block or complete AV block)
Exclusion
Key Trial Info
Start Date :
May 19 2017
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
October 27 2019
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT03252613
Start Date
May 19 2017
End Date
October 27 2019
Last Update
December 24 2018
Active Locations (2)
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1
Stanford University
Stanford, California, United States, 94305
2
Intermoutain Medical Center
Murray, Utah, United States, 84157