Status:
UNKNOWN
A Study of Using Parenchymal Blood Volume(PBV) for Endovascular Treatment of Renal Arterial Stenosis
Lead Sponsor:
Peking Union Medical College Hospital
Conditions:
Renal Artery Stenosis
Renal Blood Perfusion
Eligibility:
All Genders
18+ years
Brief Summary
This study will use PBV technique to quantitatively assess the improvement of renal perfusion before and after endovascular treatment (EVT) of renal artery stenosis.
Detailed Description
BACKGROUND: Renal artery stenosis (RAS) is one of the main reasons for secondary hypertension and renal failure, which etiologies include atherosclerosis, fibromuscular dysplasia and takayasu arteriti...
Eligibility Criteria
Inclusion
- Patients should meet all of the following criteria:
- Age ≥ 18.
- Renal artery stenosis is greater than or equal to 80% and less than 100% by duplex, CT angiography or magnetic resonance angiography.
- The target kidney remains functional(tested by radionuclide imaging)
- Documented history of hypertension on two or more anti-hypertensive medications OR estimated glomerular filtration rate (eGFR) less than 60 mL per minute per 1.73 m\^2, calculated by the modified Modification of Diet in Renal Disease formula.
- The length of target kidney is \>8cm.
Exclusion
- Patients meet any of the following criteria should be excluded.
- Unable or willing to comply with study protocol or procedures.
- Pregnancy or lactation.
- History of kidney transplant.
- Currently in acute pulmonary edema OR systolic ejection fraction of heart \<30% OR respiratory failure due to hypertension or acute coronary syndrome or cerebrovascular accident in past 3 months.
- The eGFR is less than 15 mL per minute per 1.73 m\^2 OR serum Cr is greater than 3.0 mg/dl on the day of randomization.
- Other known reason nonischemic kidney injure(e.g. nephritis). If it is diabetic nephropathy, 24h urinary protein should be more then 3g.
- Aorta has stenosis(greater than 30%).
Key Trial Info
Start Date :
November 1 2016
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
July 1 2018
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT03252639
Start Date
November 1 2016
End Date
July 1 2018
Last Update
August 17 2017
Active Locations (1)
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1
Peking Union Medical College Hospital
Beijing, Beijing Municipality, China, 100000