Status:
COMPLETED
18F-fluorocholine PET-MR Imaging of Coronary Plaque Vulnerability
Lead Sponsor:
Maastricht University Medical Center
Collaborating Sponsors:
VieCuri Medical Centre
Stichting de Weijerhorst
Conditions:
Myocardial Infarction
Myocardial Ischemia
Eligibility:
All Genders
18+ years
Brief Summary
This study is designed as a prospective observational feasibility study. The investigators will study whether vulnerable plaques on OCT (fibrous cap ≤ 70 μm) show a locally increased uptake of 18F-cho...
Detailed Description
Background of the study: Myocardial infarction (MI) frequently recurs after MI, which may be related to insufficient vulnerable plaque identification using invasive coronary angiography. More accurat...
Eligibility Criteria
Inclusion
- Group 1 - Protocol optimization: only additional PET-MRI
- Diagnosed with stable angina pectoris and scheduled for a PCI procedure at the MUMC
- Minimum age of 18 years
- Mentally competent
- Having provided informed written consent
- Group 2 - Patients included at Viecuri hospital: additional PET-MRI and OCT
- NSTEMI or STEMI patients who underwent urgent percutaneous coronary intervention (PCI) of the culprit vessel, who are diagnosed with multivessel coronary disease and are currently scheduled for a second PCI at the VieCuri hospital
- Currently stable and scheduled for another PCI at the VieCuri hospital to stent another coronary vessel
- Able to visit the MUMC by own transport / train for PET-MR imaging before the new PCI procedure
- Minimum age of 18 years
- Mentally competent
- Having provided informed written consent
- Group 3 - Patients included at MUMC+: additional PET-MRI
- Recently diagnosed with NSTEMI and scheduled for a PCI at the MUMC
- GRACE risk score between 90 and 140
- Acute Coronary Syndrome (ACS) type 1
- Minimum age of 18 years
- Mentally competent
- Having provided informed written consent
Exclusion
Key Trial Info
Start Date :
March 2 2018
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 6 2019
Estimated Enrollment :
15 Patients enrolled
Trial Details
Trial ID
NCT03252990
Start Date
March 2 2018
End Date
December 6 2019
Last Update
February 21 2020
Active Locations (1)
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1
Maastricht University Medical Centre
Maastricht, Limburg, Netherlands, 6229HX