Status:
WITHDRAWN
Safety and Efficacy of Propranolol in the Treatment of Tardive Dyskinesia
Lead Sponsor:
Emory University
Collaborating Sponsors:
Atlanta Clinical and Translational Science Institute
Conditions:
Tardive Dyskinesia
Eligibility:
All Genders
18-75 years
Phase:
PHASE2
PHASE3
Brief Summary
Tardive dyskinesia (TD) is a disabling, embarrassing and often irreversible iatrogenic movement disorder that can occur in anyone exposed to drugs that block dopamine receptors, including first and se...
Detailed Description
Tardive dyskinesia (TD) is a disabling, embarrassing and often irreversible iatrogenic movement disorder that can occur in anyone exposed to drugs that block dopamine receptors, including first and se...
Eligibility Criteria
Inclusion
- age 18-75 years
- diagnosis of classical TD by a movement disorder expert for at least 6 months with a baseline score of at least 2 on two of the seven items on the AIMS severity scale
- stable on medication (either on or off dopamine blocking agents) for at least six months.
Exclusion
- breastfeeding
- pregnant
- unstable psychiatric disease
- history of asthma or COPD
- baseline heart rate less than 60
- history of orthostatic hypertension or its presence at screening
- history of congestive heart failure or unstable angina pectoris
- resting SBP \<100 and DBP \< 60
- AV-block II or III without pacemaker
- history of diabetes mellitus
- previous adverse effects from use of beta-blockers
- current use of a β-blocker and the other following drugs: quinidine, amiodarone, propafenone, digoxin, verapamil, diltiazem, clonidine, and warfarin
- tremor, dystonia, akathisia or other non-tardive movement disorder
- any medical illness that precludes treatment with propranolol.
Key Trial Info
Start Date :
September 18 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2019
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT03254186
Start Date
September 18 2017
End Date
February 1 2019
Last Update
February 26 2019
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