Status:
COMPLETED
Cue-Reward Learning and Weight Gain in Youth
Lead Sponsor:
University of California, San Diego
Collaborating Sponsors:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
National Institutes of Health (NIH)
Conditions:
Overweight
Obesity
Eligibility:
All Genders
8-11 years
Brief Summary
The objective of the study is to compare children at low risk for obesity (two healthy weight parents) to children at high risk for obesity (two overweight parents) in their response rate to food tast...
Detailed Description
The primary aim of this project is to conduct an adequately powered study that compares children at low risk for obesity to children at high risk for obesity on their brain responses to food tastes du...
Eligibility Criteria
Inclusion
- Healthy weight children between the ages of 8 and 11 Years
- BMI 5-75th percentile
- Child must be right-handed
- Child must be willing to participate in an fMRI scan
- Either two biological parents who are overweight/obese or no biological parents that are overweight/obese
- One biological parent willing to bring child to assessment visits
- Child and participating parent Fluent in English for speaking, reading, and writing
- Child must like cheese pizza and chocolate milkshake
Exclusion
- Child overweight (BMI≥85th percentile)
- Child diagnoses of a serious chronic physical disease (e.g., diabetes) for which physician supervision of diet and exercise prescription are needed
- Child who is taking medications that may impact brain responses (can take kids who are stable on meds)
- Child with MRI contraindications (presence of metallic foreign object or device in body, piercings that cannot be removed, tattooed permanent makeup that contain metal, braces, head trauma, claustrophobia, use of Bigen permanent hair dye)
- Child with an active eating disorder (reported on EDE interview) or with first degree relative with Anorexia Nervosa or Bulimia Nervosa
- Cognitive impairment or disability determined through parent and child self-report measures, and parent reported child individual education plan
- Vision problems uncorrectable with lenses
- Food allergies related to cheese pizza, chocolate milkshake, or the snack foods used in the study
- Menarche in female participants at time of enrollment
- Children scoring within the midpubertal range or higher based on the Pubertal Development Scale
Key Trial Info
Start Date :
December 1 2016
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 27 2023
Estimated Enrollment :
147 Patients enrolled
Trial Details
Trial ID
NCT03254576
Start Date
December 1 2016
End Date
December 27 2023
Last Update
January 29 2024
Active Locations (1)
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1
UCSD Center for Healthy Eating and Activity Research (CHEAR)
La Jolla, California, United States, 92093