Status:
COMPLETED
Comparison of Lipophilic Versus Hydrophilic Statins on Patients With Heart Failure
Lead Sponsor:
Ain Shams University
Conditions:
Heart Failure
Eligibility:
All Genders
18-75 years
Phase:
PHASE4
Brief Summary
There is a controversy whether statins are beneficial in patients with heart failure or not. Trials in which lipophilic statins have been used revealed positive results, unlike major studies where hyd...
Eligibility Criteria
Inclusion
- older than 18 years (of both sexes)
- diagnosed with stable chronic heart failure NYHA class II-III
- ejection fraction \< 40 % as assessed by 2D echocardiography
- who have been optimized on Guideline Directed treatment for heart failure for at least a month prior to enrolling.
Exclusion
- Known hypersensitivity to statin
- Treatment with statins during the past month prior to study.
- Serum creatinine \> 3 mg/dl
- Significant liver disease: liver enzymes 2.5 folds the upper normal limit
- Malignancy
- Pregnancy or lactation
Key Trial Info
Start Date :
June 15 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2019
Estimated Enrollment :
85 Patients enrolled
Trial Details
Trial ID
NCT03255044
Start Date
June 15 2017
End Date
April 1 2019
Last Update
January 9 2020
Active Locations (1)
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1
Ain Shams University Hospital Cardiology Rehab Unit
Cairo, Egypt