Status:
UNKNOWN
Cerebral Blood Flow and Ventilatory Responses During Sleep in Normoxia and Intermittent Hypoxia
Lead Sponsor:
University of Calgary
Conditions:
Obstructive Sleep Apnea of Adult
Hypoxia, Brain
Eligibility:
All Genders
18-45 years
Phase:
PHASE1
PHASE2
Brief Summary
A prospective double blind, placebo-controlled, randomized cross-over trial to evaluate the effect of lowering cerebral blood flow on the ventilatory chemoreflexes (acute hypoxic and hypercapnic venti...
Detailed Description
The investigators will explore the relationship between changes in Cerebral Blood Flow (CBF) and ventilatory chemoreflexes i.e. Acute Ventilatory Response to Hypoxia (AHVR) and Acute Hypercapnic Venti...
Eligibility Criteria
Inclusion
- Healthy adults
- 18 - 45 years of age
- Living in Calgary for the past one year
- Have no medical condition or should not be taking any blood pressure medications.
- The participant should not be lactose intolerant
Exclusion
- Cerebrovascular, cardio-respiratory, renal and metabolic diseases
- Bleeding disorders and upper gastrointestinal diseases e.g. peptic ulcer disease
- Pregnancy, obese and sleep-disordered breathing
- Drug allergies to non-steroidal anti-inflammatories
- Currently smoking
Key Trial Info
Start Date :
January 1 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 30 2024
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT03255408
Start Date
January 1 2023
End Date
December 30 2024
Last Update
November 4 2022
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