Status:
UNKNOWN
Application of Diffusion Tensor Imaging in Alzheimer's Disease :Quantification of White Matter Micro-structural Changes
Lead Sponsor:
Assiut University
Conditions:
Alzheimer Dementia
Eligibility:
All Genders
60-80 years
Brief Summary
Diffusion Tensor imaging of white matter degeneration in Alzheimer disease
Detailed Description
Alzheimer's disease (AD) is the most common cause of dementia in the elderly, accountings for 60-70% of all demented cases. It is a neuro-pathological diagnosis determined by presence of neurofibrilla...
Eligibility Criteria
Inclusion
- cognitive complaints with interference in complex occupational and social activities.
- changes in cognition reported by the patient ,informant or clinician.
- absence of profound sub-cortical ischemic changes.
Exclusion
- state of delirium
- stroke event within 2 weeks
- appearance of cortical and /cortico-subcortical non -lacunar territorial infarcts and watershed infarcts ,hemorrhage ,signs of normal pressure hydrocephalus ,and specific causes of white matter lesions (e.g. multiple sclerosis, sarcoidosis, brain irradiation)
- derangements in serology tests contributing to cognitive impairment (e.g. abnormal levels of free T4 or rapid plasma reagin.
- severe hearing or visual impairment.
- cases of severe dementia.
Key Trial Info
Start Date :
September 29 2017
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2022
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT03255720
Start Date
September 29 2017
End Date
December 31 2022
Last Update
September 26 2017
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