Status:
COMPLETED
Natriuresis as a Predictor of the Haemodynamic Response to Steroid Replacement Therapy in Patients in Septic Shock
Lead Sponsor:
Centre Hospitalier Universitaire Dijon
Conditions:
Septic Shock
Eligibility:
All Genders
18-85 years
Brief Summary
Septic shock is responsible in 20% of cases of acute adrenal insufficiency and in 50% of cases of chronic 'slow' adrenal insufficiency. Given the unpredictable nature of the response to the ACTH stimu...
Eligibility Criteria
Inclusion
- persons who have consented to take part
- Patients aged 18 to 85 years
- Admitted to an ICU for a first episode of septic shock
- With a dose of noradrenaline ≥ 0.25µg/kg/min
- Undergoing treatment with Hydrocortisone Hemisuccinate (HCHS)
Exclusion
- Adult under guardianship
- Patients without national health insurance cover
- Pregnant or breast-feeding women
- Immunodepression (AIDS, corticosteroid treatment \> 3 weeks, Organ graft, treatment with immunosuppressants)
- Recent intake of diuretics (\< 6 h)
- Long-term ACE inhibitors or ARAII
- Chronic kidney failure (clearance \< 60)
- Cirrhosis Child ≥ B
- Chronic heart failure (NYHA III and IV)
- Decision to limit or to stop treatment
Key Trial Info
Start Date :
February 27 2017
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 15 2017
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT03258619
Start Date
February 27 2017
End Date
November 15 2017
Last Update
February 28 2024
Active Locations (1)
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1
Chu Dijon Bourgogne
Dijon, France, 21000