Status:
COMPLETED
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Sepsis and Septic Shock
Lead Sponsor:
Zhujiang Hospital
Conditions:
Sepsis
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
In this prospective clinical study, the investigators compare the outcome and clinical course of consecutive septic participants treated with intravenous vitamin C, hydrocortisone, and thiamine (treat...
Detailed Description
A prospective randomized controlled trial is conducted.One hundred and forty severe sepsis or septic shock participants admit to the Department of Critical Care Medicine of Zhujiang Hospital,Southern ...
Eligibility Criteria
Inclusion
- A primary diagnosis of sepsis or septic shock (the diagnoses of sepsis and septic shock are based on the 2016 the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)) and a procalcitonin (PCT) level≥2ng/mL.
- Sepsis: Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection.
- Septic shock: Septic shock is a subset of sepsis in which underlying circulatory and cellular/metabolic abnormalities are profound enough to substantially increase mortality.
Exclusion
- Patients \< 18 years of age, pregnant patients, and patients with limitations of care.
Key Trial Info
Start Date :
September 25 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 2 2019
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT03258684
Start Date
September 25 2017
End Date
February 2 2019
Last Update
March 12 2019
Active Locations (1)
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1
Department of Critical Care Medicine of Zhujiang Hospital,Southern Medical University
Guangzhou, Guangdong, China, 510282