Status:
TERMINATED
Effects of rTMS on Human Brain Activity Measured With fMRI
Lead Sponsor:
Duke University
Conditions:
Human Brain Activity
Eligibility:
All Genders
18-30 years
Phase:
NA
Brief Summary
This project investigates the effects of repetitive transcranial magnetic stimulation (rTMS) on neural circuits as a function of spatiotemporal parameters and brain state in order to better understand...
Eligibility Criteria
Inclusion
- Age between 18-30.
- Use of effective method of birth control for women of childbearing capacity.
- Willing to provide informed consent.
Exclusion
- Current or recent (within the past 6 months) of substance abuse or dependence, excluding nicotine and caffeine (urine test).
- Current serious medical illness (self report).
- History of seizure except those therapeutically induced by ECT (childhood febrile seizures are acceptable and these subjects may be included in the study), history of epilepsy in self or first degree relatives, stroke, brain surgery, head injury, cranial metal implants, known structural brain lesion, devices that may be affected by rTMS or MRI (pacemaker, medication pump, cochlear implant, implanted brain stimulator); \[TMS Adult Safety Screening (TASS) form\].
- Subjects are unable or unwilling to give informed consent.
- Diagnosed any Axis I DSM-IV disorder (MINI, DSM-IV)
- Subjects with a clinically defined neurological disorder including, but not limited to:
- Any condition likely to be associated with increased intracranial pressure
- Space occupying brain lesion.
- History of stroke.
- Transient ischemic attack within two years.
- Cerebral aneurysm.
- Dementia.
- Mini Mental Status Exam (MMSE) score of \<24.
- Parkinson's disease.
- Huntington's disease.
- i. Multiple sclerosis.
- Increased risk of seizure for any reason, including prior diagnosis of increased intracranial pressure (such as after large infarctions or trauma), or currently taking medication that lowers the seizure threshold.
- Subjects with cochlear implants
- Subjects not willing to tolerate the confinement associated with being in the MRI scanner.
- Women who are pregnant or breast-feeding (urine test).
- Blindness.
- Inability to read or understand English.
Key Trial Info
Start Date :
January 12 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 20 2019
Estimated Enrollment :
27 Patients enrolled
Trial Details
Trial ID
NCT03259568
Start Date
January 12 2018
End Date
August 20 2019
Last Update
March 29 2023
Active Locations (1)
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1
Duke University Medical Center
Durham, North Carolina, United States, 27705