Status:
UNKNOWN
Measurement of Renal Functional Reserve Change In Patients With SRC Before and After Laparoscopic Deroofing
Lead Sponsor:
ou tongwen
Conditions:
Simple Renal Cyst
Eligibility:
All Genders
18-90 years
Phase:
NA
Brief Summary
Renal functional reserve may be improved in patients with simple renal cysts after laparoscopic deroofing.
Detailed Description
Simple renal cysts (SRC) are the most frequent type of cystic renal disease. The prevalence rate of SRCs is about 10% and increases with age. Hypertension and decreased renal functions have been repor...
Eligibility Criteria
Inclusion
- Age ≥18
- Estimated GFR \>30 mL/min/1.73m2
- Subjects who signed informed consent forms
Exclusion
- Allergy to iothalamate, shellfish or iodine
- Use of metformin or amiodarone
- Inability to maintain a stable regimen of medications which affect GFR for \> one week prior to participation (e.g. non-steroidal anti-inflammatory drugs, angiotensin converting enzyme inhibitors, angiotensin receptor blockers)
- Use of medications which directly affect elimination of creatinine (e.g. cimetidine and trimethoprim)
- Acute exacerbation of asthma or chronic obstructive pulmonary disease within 3 months requiring hospitalization or oral steroid therapy
- Inadequate intravenous access
- Severe anemia (Hct \<21%)
- Acute kidney injury (rise in creatinine to ≥1.5 times the previous baseline or by ≥ 0.3 mg/dL on most recent labs prior to enrollment)
- History of contrast-induced nephropathy
- Hyperthyroidism
- Pheochromocytoma
- Sickle cell disease
- Urinary retention or incontinence
- Status post organ transplant
- Pregnancy or active breast feeding
- Cognitive impairment with inability to give consent
- Institutionalized status
Key Trial Info
Start Date :
March 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2021
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT03259594
Start Date
March 1 2018
End Date
December 31 2021
Last Update
April 29 2020
Active Locations (1)
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1
Xuanwu Hospital Capital Medical University
Beijing, Beijing Municipality, China, 100053