Status:
COMPLETED
HEMOglobin Transfusion Threshold in Traumatic Brain Injury OptimizatioN: The HEMOTION Trial
Lead Sponsor:
CHU de Quebec-Universite Laval
Collaborating Sponsors:
Canadian Critical Care Trials Group
Canadian Traumatic Brain Injury Research Consortium
Conditions:
Traumatic Brain Injury
Transfusion
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Most trauma deaths are related to traumatic brain injury (TBI). Although the management of patients has improved, mortality remains unacceptably high, and half of survivors of moderate and severe TBI ...
Eligibility Criteria
Inclusion
- Acute moderate to severe blunt TBI
- Glasgow Coma Score \[GCS\] ≤ 12
- Hb level ≤ 100 g/L
Exclusion
- Patient has received transfusion after ICU admission
- Contraindications or known objection to transfusions
- Glasgow Coma Scale (GCS) of 3 with dilated fixed pupils.
- Patient is brain dead
- Active life-threatening bleeding with hemorrhagic shock or requiring urgent surgical procedure
- A decision to withold or withdraw life-sustaining therapies was made
- No fixed address
Key Trial Info
Start Date :
August 31 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 16 2024
Estimated Enrollment :
742 Patients enrolled
Trial Details
Trial ID
NCT03260478
Start Date
August 31 2017
End Date
February 16 2024
Last Update
May 3 2024
Active Locations (33)
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1
Santa Casa de Misericórdia de Barretos
Barretos, São Paulo, Brazil
2
The Hospital das Clinicas da Facudade de Medicina da USP
São Paulo, Brazil
3
Foothills Medical Center
Calgary, Alberta, Canada
4
Royal Alexandra Hospital
Edmonton, Alberta, Canada