Status:
UNKNOWN
Impact of Acute and Chronic Inflammation on Cytochromes P450 Activity Measured With Dried Blood Spot
Lead Sponsor:
University Hospital, Geneva
Conditions:
Inflammation
Eligibility:
All Genders
18+ years
Brief Summary
Cytochromes P450, main enzymes of drug metabolism, play a prominent role in the first-pass metabolism of oral substances. Inter-individual variability in their activity due to genetic and environmenta...
Eligibility Criteria
Inclusion
- -\> For hip surgery and chronic inflammation groups
- Male and female patients diagnosed with rheumatoid arthritis or undergoing an elective hip surgery
- Age \> 18 years old
- Understanding of French language and ability to give a written inform consent
- For SARS-CoV-2 infection group
- Male and female patients diagnosed with SARS-CoV-2 infection (positive RT-PCR) and CRP \> 30 mg/L
- Age \> 18 years old
- Understanding of French language and ability to give a written inform consent
- -\>
Exclusion
- For hip surgery and chronic inflammation groups
- Pregnant or lactating females
- Severe cardiac failure, severe edema or ascites
- Severe COPD or pulmonary embolism requiring oxygen
- Uncontrolled infection
- Active cancer
- HIV infection
- Renal impairment (defined as serum creatinine concentrations \> 1.5 x ULN)
- Hepatic impairment (alteration of hepatic tests AST, ALT, bilirubin, GGT \>2 x ULN)
- Inability to give blood samples
- Sensitivity to any of the drugs used
- Intake of drugs altering CYPs activity (based on \[1\]) except for tocilizumab
- For SARS-CoV-2 infection group
- Pregnant or lactating females
- Hospitalized in intensive care unit at time of inclusion
- Hospitalized in intermediate care unit at time of inclusion
- Active cancer
- HIV infection
- Renal impairment (glomerular filtration rate \< 30 mL/min/1.73m2)
- Hepatic impairment (Child-Pugh score B and C)
- Inability to give blood samples
- Sensitivity to any of the drugs used
Key Trial Info
Start Date :
September 1 2017
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 1 2021
Estimated Enrollment :
106 Patients enrolled
Trial Details
Trial ID
NCT03262051
Start Date
September 1 2017
End Date
September 1 2021
Last Update
March 4 2021
Active Locations (1)
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1
Geneva University Hospitals, HUG
Geneva, Switzerland