Status:
COMPLETED
Mediastinitis and Staphylococcus Aureus
Lead Sponsor:
Rennes University Hospital
Conditions:
Surgery, Cardiac
Infection
Eligibility:
All Genders
18+ years
Brief Summary
Cardiac surgery with extracorporeal circulation (ECC) yields a deep immune system dysfunction that exposes patients to postoperative infectious complications. Among these, post-operative mediastinitis...
Detailed Description
In particular, changes induced by the ECC will be evaluated on: * Indoleamine 2,3-dioxygenase activity (IDO) * Apoptosis of lymphocytes and dendritic cells * Polymorphonuclear neutrophils (PMNs) * My...
Eligibility Criteria
Inclusion
- Inclusion criteria
- Patients over 18 years of age
- Patients who require cardiac surgery (valvular and / or coronary) with extracorporeal circulation.
- Non inclusion criteria
- Chronic respiratory diseases,
- Preoperative left ventricular dysfunction (LVEF \<50%),
- Immunosuppression (HIV infection, systemic corticosteroid therapy, history of cancer in the year before surgery),
- Persons subject to legal protection (safeguard of justice, curatorship, guardianship),
- Persons deprived of liberty.
Exclusion
Key Trial Info
Start Date :
July 4 2016
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
September 29 2019
Estimated Enrollment :
27 Patients enrolled
Trial Details
Trial ID
NCT03262558
Start Date
July 4 2016
End Date
September 29 2019
Last Update
December 14 2022
Active Locations (1)
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1
Rennes Hospital University
Rennes, France, 35033