Status:
COMPLETED
Effects of Dehydration on Neuromuscular Performance and Sympathetic Control of Cardiovascular Function
Lead Sponsor:
United States Army Research Institute of Environmental Medicine
Conditions:
Dehydration Hypertonic
Isotonic Dehydration
Eligibility:
All Genders
18-45 years
Phase:
NA
Brief Summary
The mechanism(s) by which dehydration (both intra- and extracellular) impairs performance are still poorly described. A loss of volume results in increased occurrence of orthostatic intolerance, inclu...
Detailed Description
Study Objectives and Hypotheses Primary Objective The primary objectives of this study are to understand the in vivo effects of dehydration on: 1. Sympathetic neural control of cardiovascular funct...
Eligibility Criteria
Inclusion
- Male or female, age 18-45
- In good health as determined by OMSO General Medical Clearance
- Passed his/her most recent Army Physical Fitness Test (APFT) (military volunteers only) or exercise at least 2 times per week (civilian volunteers)
- Ability to comprehend and willingness to sign informed consent
Exclusion
- Females who are pregnant or planning to become pregnant during the study
- Taking prescription or over the counter medication, other than a contraceptive (unless approved by OMSO and PI)
- Physical problems/injuries associated with walking or cycling
- Allergy to sulfa drugs (Lasix™ or sulfonamide antibiotics such as Septra™)
- Allergy to skin adhesive
- Hemoglobinopathy (sickle cell trait)
- Heart, lung, kidney, muscle, or nerve disorder(s)
- History of heat or orthostatic intolerance
- Diagnosed and/or treated for fluid/electrolyte imbalance within the last 30 days
- Presence of metal implants/electronic medical devices in lower extremities
- Current or previous (within the past 5 years) diagnosis of any autonomic disorder, including idiopathic orthostatic intolerance, orthostatic hypotension, postural tachycardia syndrome (POTS), or neurocardiogenic syncope (MSNA group only)
- Tobacco/nicotine use (MSNA group only)
- Significant muscle, joint, or bone injury affecting the legs within the last 6 months (CAC group only)
- Difficulty swallowing large pills
- History of obstructive disease of the gastrointestinal tract including (but not limited to) diverticulosis, diverticulitis and inflammatory bowel disease, peptic ulcer disease, Crohn's disease, ulcerative colitis; or previous gastrointestinal surgery.
Key Trial Info
Start Date :
October 31 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2017
Estimated Enrollment :
43 Patients enrolled
Trial Details
Trial ID
NCT03263975
Start Date
October 31 2014
End Date
December 1 2017
Last Update
April 22 2020
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