Status:
COMPLETED
Clinical and Imaging Trial of Uridine for Veterans With Suicidal Ideation
Lead Sponsor:
VA Office of Research and Development
Conditions:
Suicidal Ideation
Eligibility:
All Genders
18-55 years
Phase:
PHASE4
Brief Summary
This is a randomized, double-blind, placebo-controlled study of the investigational drug uridine as a treatment for suicidal ideation in veterans. The investigators hypothesize that the administratio...
Detailed Description
Veteran suicides, attempts and suicidal ideation (SI) remain an urgent concern for the Veterans Health Administration (VHA). Research indicates that approximately half of veteran suicides take place w...
Eligibility Criteria
Inclusion
- Must be able to Provide Informed Consent.
- Must be a Veteran of the U.S. Armed Forces.
- Columbia-Suicide Severity Rating Scale Indicates Current Suicidal Ideation
- Beck Scale for Suicide Ideation Score \> 3 (i.e. "Greater Than or Equal to 4").
- History of \> 1 Suicide Attempt or Hospitalization to Prevent Suicide in Past 12 Months; or Functionally Impairing Suicidal Ideation Not Due to a DSM Axis II Diagnosis, in the Past 12 Months.
- Females and Males Ages 18-55 Inclusive.
- Willing and Able to Identify an Alternative Contact Person, e.g. Family Member, Friend or Neighbor.
Exclusion
- Schizophrenia or Other Psychotic Disorder.
- Active Substance Use Disorder Requiring Stabilization (N.B. Does Not Include Nicotine).
- Unstable Medical Condition(s).
- Pregnancy or Breastfeeding.
- Contraindication to MRI (e.g. Ferrometallic Implant or Claustrophobic Anxiety).
- Concurrent Enrollment in Another Clinical Trial.
- Significant Risk of Protocol Non-Adherence (e.g. resides \> 50 miles from the hospital, and has no automobile or alternate transportation).
Key Trial Info
Start Date :
April 2 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 30 2024
Estimated Enrollment :
75 Patients enrolled
Trial Details
Trial ID
NCT03265964
Start Date
April 2 2018
End Date
June 30 2024
Last Update
August 15 2025
Active Locations (1)
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1
VA Salt Lake City Health Care System, Salt Lake City, UT
Salt Lake City, Utah, United States, 84148-0001