Status:
COMPLETED
Inspiratory Muscle Strength Training to Improve Blood Pressure and Physiological Function
Lead Sponsor:
Douglas Seals
Conditions:
Hypertension
Prehypertension
Eligibility:
All Genders
50-64 years
Phase:
NA
Brief Summary
The purpose of this study is to assess the efficacy of inspiratory muscle strength training for lowering blood pressure and improving physiological function (vascular, motor, and cognitive) in middle-...
Detailed Description
Over, the proposed research project has the long-term potential to influence clinical practice by establishing a novel lifestyle intervention for treating multiple domains of age- and hypertension-ass...
Eligibility Criteria
Inclusion
- Ability to provide informed consent
- Willing to accept random assignment to condition
- Women will be confirmed as postmenopausal (either natural or surgical) based on cessation of menses for \>1 year.
- Resting systolic blood pressure 120-159 mmHg
- Resting diastolic blood pressure \<100 mmHg
- Subjects taking anti-hypertensive medications will be included provided they meet the other inclusion criteria, including elevated systolic blood pressure. These medications will not be withheld prior to experimental protocols.
- Free from alcohol dependence or abuse, as defined by the American Psychiatry Association, Diagnostic and Statistical Manual or Mental Disorders (DSM-IV)
Exclusion
- Current smoking
- Chronic clinical disease (e.g., inflammatory bowel disease/irritable bowel syndrome, coronary artery/peripheral artery/cerebrovascular diseases, diabetes, chronic kidney disease requiring dialysis, neurological disorders or diseases that may affect motor/cognitive function \[multiple sclerosis, Parkinson's disease, polio, Alzheimer's disease, dementia, or other brain diseases of aging\]), except hypertension
- Postmenopausal \<1 year
- Scoring \<21 on the mini-mental state examination
- Moderate or sever peripheral artery disease (ankle-brachial index 0.7)
- Taking a medication that your doctor deems unsafe to hold for \>1 week
- A graded exercise test will be performed by all subjects. If there is physician concern or an adverse event, the subject will not participate in the study.
- No weight stable in the prior 3 months (\>2 kg weight change) or unwilling to remain weight stable throughout study (rationale: recent weight change or weight loss can influence vascular function)
Key Trial Info
Start Date :
November 25 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 30 2020
Estimated Enrollment :
64 Patients enrolled
Trial Details
Trial ID
NCT03266510
Start Date
November 25 2017
End Date
October 30 2020
Last Update
May 7 2021
Active Locations (1)
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1
Integrative Physiology of Aging Laboratory
Boulder, Colorado, United States, 80309