Status:
COMPLETED
A Study of Exosome Proteomics and Hemodynamics in Sepsis
Lead Sponsor:
Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
Conditions:
Hemodynamic Instability
Autophagy
Eligibility:
All Genders
20-99 years
Brief Summary
This research will be the first study for exosomes purified in blood and urine from septic patients who had multiple organ failures. Proteomics studies in exosomes from blood or urine specimens. Analy...
Detailed Description
Background: Sepsis, defined as an infection with evidence of systemic infection, continues to be a source of considerable morbidity and mortality. Many animal sepsis models had found that sepsis induc...
Eligibility Criteria
Inclusion
- Patients with sepsis who admit to ICU
- Sepsis diagnostic criteria: acute change in total SOFA score ≥ 2 points attributable to infection
- Pulse indicator continuous cardiac output monitor (PiCCO) is accept by patient for hemodynamic monitoring
Exclusion
- Patients with acute SOFA changes \< 2 points are excluded
- auria, no urine can be collected
- Previous cardiopulmonary co-morbidity. Chronic respiratory failure with ventilator dependence and chronic heart failure.
Key Trial Info
Start Date :
January 18 2017
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 30 2020
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT03267160
Start Date
January 18 2017
End Date
January 30 2020
Last Update
February 10 2021
Active Locations (1)
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1
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
Taipei, Taiwan, 23142