Status:
UNKNOWN
Evaluate the Safety and Efficacy of CAR-T in the Treatment of Pancreatic Cancer.
Lead Sponsor:
First Affiliated Hospital of Harbin Medical University
Collaborating Sponsors:
Shanghai Unicar-Therapy Bio-medicine Technology Co.,Ltd
Conditions:
Pancreatic Cancer
CAR
Eligibility:
MALE
18-65 years
Phase:
EARLY_PHASE1
Brief Summary
Immunotherapy has become the major breakthrough and the most promising treatment, with the host of development of tumor biology, molecular biology and immunology. It has become the fourth tumor treatm...
Detailed Description
Immunotherapy has become the major breakthrough and the most promising treatment, with the host of development of tumor biology, molecular biology and immunology. It has become the fourth tumor treatm...
Eligibility Criteria
Inclusion
- Imaging, pathology or biopsy confirmed as pancreatic cancer and it has metastasized, can not radical cured by surgery; patients restored good but there is still residual lesions, recurrence or metastasis 1 months after surgery;
- Accepted more than 1 times chemotherapy which is invalid or unwilling to accept previous chemotherapy patients;
- The corresponding antigens such as Meso and PSCA/ CEA/ HER2/ MUC1/ EGFRvIII were highly expressed;
- Male patients aged between 18 and 65;
- Life expectancy greater than 1 months;
- Karnofsky score ≥ 60, ECOG≤ 2;
- Important organ function as defined by the following: cardiac ejection fraction ≥ 50%; electrocardiogram showed no obvious abnormalities; creatinine clearance rate calculated by using Cockcroft- Gault formula ≥40ml/min ; ALT/AST≤ 3×the institution normal upper limit; total bilirubin ≤2.0mg/dl; coagulation function: PT/ APPT\<2 ×the institution normal upper limit; SpO2 \>92%; Blood: hemoglobin\>80g/L, ANC ≥ 1, PLT ≥ 50×109/L;
- There is measurable target lesion;
- Voluntary informed consent is given.
Exclusion
- Immunosuppressive drugs or hormones were used a week before admission;
- Severe active infection;
- Human immunodeficiency virus (HIV) positive;
- Active hepatitis B or C infection;
- Past medical history of other malignancies. Not included: patients who have been cured at any time prior to the treatment of the skin basal or squamous cell carcinoma and cervical carcinoma in situ; the other tumor has not listed above, but has been used and only cured by surgery, without further treatment by other measures, the subjects of disease-free survival more than 5 years, can be included in the study;
- Patients participating in other clinical trials;
- The researchers thought the subjects were unfit for inclusion or unable to participate in or complete the study；
- Patients with congenital immunodeficiency；
- There is a history of myocardial infarction and serious arrhythmia within six months.
Key Trial Info
Start Date :
June 15 2017
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2019
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT03267173
Start Date
June 15 2017
End Date
June 1 2019
Last Update
August 30 2017
Active Locations (1)
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1
Harbin Medical University
Harbin, Heilongjiang, China, 150001