Status:
COMPLETED
PET Study of the Nicotinic System in Epilepsy
Lead Sponsor:
Fabienne PICARD
Conditions:
Epilepsy
Eligibility:
MALE
18-60 years
Phase:
NA
Brief Summary
Mutations in neuronal nicotinic acetylcholine receptors (nAChRs) have been identified in the autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE). Despite the demonstration of a gain of functio...
Eligibility Criteria
Inclusion
- males
- 18-60 years old
- non-smokers
Exclusion
- smoking during the past twelve months
- contraindications to MRI
- brain lesions on MRI (including hippocampal atrophy)
- neurological disorder (other than epilepsy) or psychiatric disorder
- neoplasia or coronary disease
- blood test showing : creatinine clearance \< 50 ml/min, or platelet \< 100 G/l, or leucocytes \< 3.8 G/l, or ALT or AST \> 2 x upper standard, or gamma-GT \> 3 x upper standard, or albumin \< 35 g/l or \> 48 g/l .
- patients only : nuclear imaging during the past twelve months
- healthy volunteers only : ionising radiation exam during the past five years
Key Trial Info
Start Date :
February 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2015
Estimated Enrollment :
48 Patients enrolled
Trial Details
Trial ID
NCT03268369
Start Date
February 1 2012
End Date
November 1 2015
Last Update
August 31 2017
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