Status:
COMPLETED
Neuroimaging During Pure Oxygen Breathing
Lead Sponsor:
Case Western Reserve University
Conditions:
Hyperoxia
Hypoxia, Brain
Eligibility:
All Genders
18-60 years
Phase:
PHASE4
Brief Summary
The investigators will conduct a non-randomized clinical trial to examine the effect of pure oxygen breathing on the brain. The study will compare cerebral blood flow, cortical electrical activity, an...
Detailed Description
The investigators will conduct a crossover design clinical trial to compare the effect of room air breathing (21% inspired oxygen) with pure oxygen breathing (100% inspired oxygen) on brain blood flow...
Eligibility Criteria
Inclusion
- Persons recruited from currently approved Human Subject Panel for high altitude studies at Wright Patterson Air Force Base, Dayton, OH. Volunteers will have documentation of past exposure to hypobaric conditions, either from past high-altitude flight, as hypobaric chamber personnel, or as participants in previous/current high altitude studies. Persons without past exposure to hypobaric conditions were also eligible to participate.
- Height 152.5-195.5 cm, weight 40-135 kg.
Exclusion
- Persons who have contraindications to MRI such as cardiac pacemakers, intracranial aneurysm clips, metallic implants or external clips within 10 mm of the head; implanted metallic devices such as pumps or previously implanted neurostimulation devices; cochlear implants, defibrillators, pacing wires, body piercings that cannot be removed, metal filings such as shrapnel, tattoos on the head and neck, or medical conditions contraindicated for MRI safety.
- History of claustrophobia
Key Trial Info
Start Date :
October 2 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 9 2018
Estimated Enrollment :
33 Patients enrolled
Trial Details
Trial ID
NCT03268590
Start Date
October 2 2017
End Date
May 9 2018
Last Update
November 13 2019
Active Locations (1)
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1
Case Western Reserve University
Cleveland, Ohio, United States, 44106