Status:
COMPLETED
Development of Reward Processing in Prenatally Exposed Adolescents and Young Adults
Lead Sponsor:
Yale University
Collaborating Sponsors:
National Institute on Drug Abuse (NIDA)
Conditions:
Pre-natal Cocaine Exposure
Risk-Taking
Eligibility:
All Genders
18-20 years
Brief Summary
Reward processing will be examined in prenatally exposed emerging adults in a longitudinal design. Participants will be followed for one year to see if neural markers of reward processing prospectivel...
Detailed Description
This cohort will be drawn from a pre-existing cohort of individuals recruited as part of an already existing study, and who have been followed since birth. Reward processing will be measured in two te...
Eligibility Criteria
Inclusion
- Ability to provide written informed consent and to comply with all study procedures.
- Healthy emerging adults between 18-20 years of age (the age of the currently followed sample at the time of the proposed start date).
Exclusion
- 1\. A serious neurological or endocrine disorder or any medical condition or treatment known to affect the brain. 2. A medical condition that requires treatment with a medication with psychotropic effects.
- 3\. Evidence of stroke or space occupying lesions observed on conventional, clinical MR images.
- 4\. Any contraindications to MRI scanning (i.e., metal implants, pacemakers, etc.) 5. History of loss of consciousness (LOC) for longer than 30 minutes or LOC with any neurological sequelae.
- 6\. DSM-5 criteria for intellectual disability. 7. Current or a history of active neurological or psychiatric disorders, such as psychosis, bipolar illness, major depression, organic brain disease, dementia or DSM-V Axis I Psychiatric Disorder, including current alcohol or substance disorders. Participants will not be excluded for substance or alcohol use, only the presence of substance disorders.
- 8\. Current pregnancy. Female participants will be excluded if they report being currently pregnant or present positive for pregnancy after being given a urine test at the time of recruitment or scanning. If they become pregnant during the one-year follow-up duration of the study after the MRI scan is completed, they will remain in the study for the quarterly follow-ups and be referred to pre-natal care if they have not begun such care already.
Key Trial Info
Start Date :
September 15 2017
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
September 14 2020
Estimated Enrollment :
78 Patients enrolled
Trial Details
Trial ID
NCT03268759
Start Date
September 15 2017
End Date
September 14 2020
Last Update
May 4 2021
Active Locations (1)
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1
Child Study Center
New Haven, Connecticut, United States, 06520