Status:
UNKNOWN
Cardiovascular Biomarkers and Lung Edema in Severe Burns Patients
Lead Sponsor:
Saint-Louis Hospital, Paris, France
Conditions:
Burns
Eligibility:
All Genders
18+ years
Brief Summary
Burn injury leads to hypovolemic then distributive shock. Fluid resuscitation remains the cornerstone of initial treatment of burn shock. However, fluid rescucitation can lead to fluid overload, which...
Eligibility Criteria
Inclusion
- Intubated mechanically-ventilated patients within the first 24 hours of admission
- And/or patients with total body surface area (TBSA) burn-injured \>20 %
- And/or patients with at least 10% full-thickness burns
- And/or receiving vasopressors within the first 24 hours of admission
- And monitored by a PiCCO system (PiCCO-2 Pulsion Medical Systems AG, Munich, Germany)
Exclusion
- Admission delay to ICU \> 24 hours post burn
- Age less than 18 years
- Pregnancy
- Chronic renal impairment with a baseline eGFR \< 15 ml/min
- Patients with chemical or electrical burns
- Coexisting non-burn trauma
- Patients moribund on admission or dead within 72 h from admission
- Patients with do-not-resuscitate orders
Key Trial Info
Start Date :
August 6 2017
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
April 6 2019
Estimated Enrollment :
36 Patients enrolled
Trial Details
Trial ID
NCT03271268
Start Date
August 6 2017
End Date
April 6 2019
Last Update
September 7 2017
Active Locations (1)
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1
Sabri SOUSSI
Paris, Île-de-France Region, France, 75010