Status:
COMPLETED
Pressure Support Ventilation (PSV) Versus Neurally Adjusted Ventilator Assist (NAVA) During Acute Respiratory Failure (ARF)
Lead Sponsor:
Post Graduate Institute of Medical Education and Research, Chandigarh
Conditions:
Respiratory Failure
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
Acute respiratory failure (ARF) is a life-threatening emergency which occurs due to impaired gas exchange. In the US, the number of hospitalisations owing to acute respiratory failure was 1,917,910 in...
Detailed Description
NIV is mode of ventilation wherein positive pressure ventilation is delivered by non-invasive interface like nasal mask, face mask, nasal plugs or helmet avoiding invasive interface by endotracheal in...
Eligibility Criteria
Inclusion
- Respiratory rate \>30 per minute
- Arterial blood gas analysis showing a PaCO2 \>45 mmHg and pH \<7.35
- PaO2/FiO2 ratio \< 300
- Use of accessory muscles of respiration or paradoxical respiration
Exclusion
- Age \<18 years or \>75 years
- Pregnancy
- PaO2/FiO2 ratio ≤100
- Hypotension (systolic blood pressure \<90 mmHg)
- Severe impairment of consciousness (Glasgow coma scale score \<8)
- Inability to clear respiratory secretions (Airway care score \[ACS\] ≥12)(27)
- Abnormalities that preclude proper fit of the NIV interface (agitated or uncooperative patient, facial trauma or burns, facial surgery, or facial anatomical abnormality)
- Subjects who have an artificial airway like tracheostomy tube or T-tube
- Contraindications for insertion of naso-/orogastric feeding tube (facial/nasal trauma, recent upper airway surgery, esophageal surgery, esophageal varices, upper gastrointestinal bleeding)
- More than two organ failures
- Unwillingness to undergo placement of nasogastric catheter
- Known phrenic nerve lesions
- Suspected diaphragmatic weakness
- Patient already on home NIV therapy for chronic respiratory failure
- Application of NIV for more than one hour for the current illness
- Failure to provide informed consent
Key Trial Info
Start Date :
October 1 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 31 2019
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT03271671
Start Date
October 1 2017
End Date
March 31 2019
Last Update
April 10 2019
Active Locations (1)
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1
Respiratory ICU, Post Graduate Institue of Medical Education and Research
Chandigarh, India, 160012