Status:
UNKNOWN
Metformin Treatment on Cognitive Impairment of Schizophrenia Co-morbid Metabolic Syndrome
Lead Sponsor:
Central South University
Conditions:
Schizophrenia
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
In this study, the investigators will investigate the impact and the related mechanism of metformin treatment on cognitive impairment of schizophrenia with a high risk of metabolic syndrome. Patients ...
Detailed Description
In this study, the investigators will investigate the impact and the related mechanism of metformin treatment on cognitive impairment of schizophrenia with a high risk of metabolic syndrome. Patients ...
Eligibility Criteria
Inclusion
- Meet the Diagnostic and Statistical Manual (DSM-5) diagnostic criteria for schizophrenia;
- Duration of illness less than 5 years with current symptoms exacerbation;
- Male and female aged 18 to 65 years;
- PANSS total score \< 60 and CDSS-C total score \< 6;
- Signed the study consent for participation;
- Patients with higher risk factors for MetS, or patients who gained weight \> 10% of their pre-drug weight within the first year after antipsychotic medication.
Exclusion
- Having a history of substance dependence or abuse or whose symptoms are caused by other diagnosable mental disorders;
- Having a history of traumatic brain injury, seizures, or other known neurological or organic diseases of the central nervous system;
- Taking antidepressants, stimulants, mood stabilizers or accepting electricity shock treatment;
- Having current suicidal or homicidal thoughts or any safety concern by research staff that cannot be managed in an inpatient setting;
- The routine blood tests showing abnormal renal, and liver function;
- Pregnant or lactating women.
Key Trial Info
Start Date :
August 28 2017
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2023
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT03271866
Start Date
August 28 2017
End Date
December 31 2023
Last Update
April 11 2023
Active Locations (1)
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1
The Second Xiangya Hospital of Central South University
Changsha, Hunan, China, 410011