Status:
UNKNOWN
Influence of Mechanical Ventilation Modes on the Efficacy of Nebulized Bronchodilator
Lead Sponsor:
Universidade Federal do Rio Grande do Norte
Conditions:
COPD
Asthma
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
Aerosol therapy is widely used in intensive care in critically ill patients that use mechanical ventilation (MV). However, there is a lack of standardization about aerosol performance in this group of...
Detailed Description
2\. OBJECTIVES 2.1 Primary • To evaluate the influence of mechanical ventilation modes in the efficacy of nebulized bronchodilator in ventilator dependent patients with obstructive pulmonary disease...
Eligibility Criteria
Inclusion
- Patients with asthma or chronic obstructive pulmonary disease (COPD) Invasive mechanical ventilation Hemodynamically stable
Exclusion
- Prescribed metered dose inhaler (MDI) or intravenous bronchodilators Undrained pneumothorax Bronchopleural fistula Chest trauma Tracheoesophageal fistula Tracheal granulomas Tracheal stenosis PEEP dependence
- Contraindicated disconnection of the MV
- Endotracheal tube diameter less than 7.5
- Do not make part of the protocol of daily sedation
- No regular ventilatory drive when with out sedation
- Do not reach a minimum tidal volume 6 ml/kg with a maximum peak pressure (PIP) of 35 cmH2O (centimeter of water) during MV.
- Do not use the same MV modes that will be tested in this study
Key Trial Info
Start Date :
April 10 2017
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 10 2019
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT03271905
Start Date
April 10 2017
End Date
December 10 2019
Last Update
May 21 2019
Active Locations (1)
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1
Cibelle Andrade Lima
Recife, Pernambuco, Brazil, 50610060