Status:
RECRUITING
Mapping Disease Pathways for Biliary Atresia
Lead Sponsor:
University of Pittsburgh
Collaborating Sponsors:
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Conditions:
Biliary Atresia
Eligibility:
All Genders
Brief Summary
This project will primarily evaluate the developmental/genetic basis of biliary atresia, the most common cause of liver failure at birth, and which accounts of half of all liver transplants performed ...
Detailed Description
Characterized by failure to drain bile from the liver due to atretic extrahepatic bile ducts, BA is corrected in less than half of all affected children with surgical reconstruction. The remainder pro...
Eligibility Criteria
Inclusion
- living individuals who were diagnosed with Biliary Atresia and received or are about to receive a liver transplant from multiple participating centers (Children's Hospital of Pittsburgh, Kings College Hospital, Children's Hospital of Birmingham, and Hospital Sírio-Libanês).
Exclusion
- No child participant in the care of the state will be enrolled, nor will patients in the care of temporary or informal guardians be enrolled
Key Trial Info
Start Date :
July 21 2016
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
July 21 2035
Estimated Enrollment :
1100 Patients enrolled
Trial Details
Trial ID
NCT03273049
Start Date
July 21 2016
End Date
July 21 2035
Last Update
September 9 2025
Active Locations (1)
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1
UPMC Children's Hospital of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15224