Status:
COMPLETED
Effect of Antibiotics on Gut Microbiome and Plasma Metabolome
Lead Sponsor:
Finnish Institute for Health and Welfare
Collaborating Sponsors:
University of California, San Diego
Brigham and Women's Hospital
Conditions:
Microbial Colonization
Eligibility:
All Genders
40-74 years
Phase:
PHASE4
Brief Summary
In recent years it has been observed that the gut microbiome can produce metabolites into systemic circulation and thus have important health effects even outside the gastrointestinal system. These me...
Eligibility Criteria
Inclusion
- Prior participation in the FINRISK 2002 survey and current residence in Helsinki metropolitan area.
- Age range 40-74 years among men and 50-74 years among women.
Exclusion
- Known allergy to any antibiotic
- A course of antibiotic during the past year
- Acute infection
- Any major illness (history of myocardial infarction, stroke, diabetes, liver or kidney disease, cancer, psychiatric disease). Uncomplicated hypertension is allowed. Likewise, statin treatment and women's hormone replacement therapy are allowed.
Key Trial Info
Start Date :
October 15 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 15 2017
Estimated Enrollment :
39 Patients enrolled
Trial Details
Trial ID
NCT03273296
Start Date
October 15 2017
End Date
December 15 2017
Last Update
August 19 2025
Active Locations (1)
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1
Finnish Institute for Health and Welfare
Helsinki, Finland, 00271