Status:
COMPLETED
Clinical Features and Airways Inflammation in Never Smokers and Smokers With COPD
Lead Sponsor:
Ministry of Scientific Research, Tunisia
Conditions:
COPD
Airway Obstruction
Eligibility:
All Genders
40+ years
Brief Summary
The aim of this study was to investigate the airway inflammatory profile and the clinical presentation of chronic obstructive pulmonary disease (COPD) in never smokers compared to smokers with COPD.
Detailed Description
40 COPD patients (21 smokers and 19 never smokers) and 28 healthy never smokers were included in the present study. Information about respiratory symptoms and comorbidities were collected. Subjects un...
Eligibility Criteria
Inclusion
- Subjects with COPD, according to GOLD criteria (smokers and never smokers). Moreover, inhaled short-acting β2-agonists were stopped at least 8h before the test and inhaled long-acting β2-agonist were stopped at least 48h before the test.
- Healthy control subjects : never smokers with normal spirometry and did not have a history of lung disease or chronic respiratory symptoms.
Exclusion
- COPD patients were excluded from the study if they had an exacerbation, a respiratory tract infection or if they used a systemic form of corticosteroid preparation (oral or intravenous injection therapy) or antibiotics within the two months prior to the study entry. Patients with other respiratory disorder like pneumonia, pulmonary emboli, congestive heart failure, lung cancer or tuberculosis were also excluded.
Key Trial Info
Start Date :
September 1 2013
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 1 2017
Estimated Enrollment :
68 Patients enrolled
Trial Details
Trial ID
NCT03274791
Start Date
September 1 2013
End Date
January 1 2017
Last Update
September 7 2017
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