Status:
COMPLETED
Effect of Androgen Deprivation Therapy on Cardiovascular Function in Prostate Cancer
Lead Sponsor:
Kansas State University
Conditions:
Prostate Cancer
Eligibility:
MALE
21-80 years
Brief Summary
The aim of this project is to determine whether androgen deprivation therapy (ADT) decreases left ventricular function in prostate cancer patients. If found successful, this may lead to improved cardi...
Detailed Description
Prostate Cancer is the second most common cancer among American men. Approximately 1 in 7 men will be diagnosed with prostate cancer during his lifetime. In prostate cancer patients alone, hypotestost...
Eligibility Criteria
Inclusion
- Give voluntary consent to participate in the study
- (Group 1) Diagnosed prostate cancer patient/survivor with a history of androgen deprivation therapy treatment
- (Group 2) Diagnosed prostate cancer patient/survivor with no history of androgen deprivation therapy treatment
- (Group 3) Cancer free
Exclusion
- History of clinical cardiovascular disease (Atherosclerotic cardiovascular disease (ASCVD) defined by history of acute coronary syndromes, myocardial infarction (MI), stable or unstable angina, coronary or other arterial revascularization, stroke, transient ischemia attack (TIA), or peripheral arterial disease presumed to be of atherosclerotic origin)
- Not met the above criteria
- Unable to provide informed consent
- History of smoking (within 6 months) or current smoker
- Major signs or symptoms suggestive of cardiovascular, pulmonary, or metabolic disease. These include pain, discomfort in the chest, neck, jaw, arms or other areas that may result form ischemia; shortness of breath at rest or with mild exertion; Dizziness or syncope; Orthopnea or paroxysmal nocturnal dyspnea; ankle edema; palpitations or tachycardia; intermittent claudication; known heart murmur; unusual fatigue or shortness of breath with usual activities
Key Trial Info
Start Date :
August 1 2017
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 31 2018
Estimated Enrollment :
18 Patients enrolled
Trial Details
Trial ID
NCT03275181
Start Date
August 1 2017
End Date
December 31 2018
Last Update
September 2 2025
Active Locations (1)
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1
Kansas State University - Clinical Integrative Physiology Laboratory
Manhattan, Kansas, United States, 66506