Status:
COMPLETED
Neural Correlates of Reward and Symptom Expression in Anorexia Nervosa
Lead Sponsor:
University of Minnesota
Conditions:
Anorexia Nervosa
Eligibility:
All Genders
18+ years
Brief Summary
The objective of this study is to identify the patterns of brain activity in reward circuitry that promote symptoms of anorexia nervosa. This project will compare weight-restored individuals with anor...
Detailed Description
Aim 1: To compare patterns of brain activity in reward circuits to typically rewarding cues and disorder-specific cues between weight-restored individuals with anorexia nervosa and non-eating disorder...
Eligibility Criteria
Inclusion
- Age \> 18 years old
- Current BMI \> 18.5 kg/m2
- Ability to read and speak in English
- Right-handed
- Weight restored Anorexia Nervosa group: 1) DSM-5 diagnosis of AN in the past 6 months, with the exception of body image disturbance and intense fear of weight gain criteria; 2) BMI \< 18.5 kg/m2 within past 6 months
Exclusion
- Medical instability or current pregnancy
- Current substance use disorder, psychosis, or bipolar-I disorder
- Contraindication for fMRI
- History of neurological disorder/injury (e.g., stroke; head injury with \> 10 minutes loss of consciousness)
- Food allergy that cannot be accommodated through substitutions to the laboratory test meal
- Lacking capacity to consent
- Non-eating disorder Control group: Current DSM-5 Axis-I diagnosis or current or past eating disorder diagnosis
Key Trial Info
Start Date :
February 28 2018
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 1 2022
Estimated Enrollment :
79 Patients enrolled
Trial Details
Trial ID
NCT03275545
Start Date
February 28 2018
End Date
August 1 2022
Last Update
September 21 2022
Active Locations (1)
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1
University of Minnesota
Minneapolis, Minnesota, United States, 55414