Status:

COMPLETED

Study to Assess the Efficacy and Safety of Ublituximab in Participants With Relapsing Forms of Multiple Sclerosis (RMS) ( ULTIMATE 1 )

Lead Sponsor:

TG Therapeutics, Inc.

Conditions:

Relapsing Multiple Sclerosis (RMS)

Eligibility:

All Genders

18-55 years

Phase:

PHASE3

Brief Summary

This study determines the Annualized Relapse Rate (ARR) in participants with RMS after 96 weeks (approximately 2 years) treatment with intravenous (IV) infusion of ublituximab/oral placebo compared to...

Eligibility Criteria

Inclusion

  • 18-55 age
  • Diagnosis of RMS (McDonald criteria 2010)
  • Active disease
  • Expanded disability status scale (EDSS) 0-5.5 (inclusive) at screening

Exclusion

  • Treatment with prior Anti-cluster of differentiate 20 (CD20) or other B cell directed treatment
  • Treatment with the following therapies at any time prior to randomization: alemtuzumab, natalizumab, teriflunomide, leflunomide and stem cell transplantation
  • Diagnosed with Primary Progressive MS (PPMS)
  • Pregnant or nursing

Key Trial Info

Start Date :

September 19 2017

Trial Type :

INTERVENTIONAL

Allocation :

ACTUAL

End Date :

November 6 2020

Estimated Enrollment :

549 Patients enrolled

Trial Details

Trial ID

NCT03277261

Start Date

September 19 2017

End Date

November 6 2020

Last Update

December 6 2021

Active Locations (14)

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Page 1 of 4 (14 locations)

1

TG Therapeutics RMS Investigational Trial Site

Carlsbad, California, United States, 92001

2

TG Therapeutics RMS Investigational Trial Site

Long Beach, California, United States, 90808

3

TG Therapeutics RMS Investigational Trial Site

Pasadena, California, United States, 91105

4

TG Therapeutics RMS Investigational Trial Site

Stanford, California, United States, 94305