Status:
ACTIVE_NOT_RECRUITING
Evaluation of Decreased Usage of Betablockers After Myocardial Infarction in the SWEDEHEART Registry (REDUCE-SWEDEHEART)
Lead Sponsor:
Karolinska Institutet
Collaborating Sponsors:
Uppsala University
The Swedish Research Council
Conditions:
Acute Myocardial Infarction
Non-ST Elevation Myocardial Infarction
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
Long-term beta-blocker therapy has not been investigated in contemporary randomized clinical trials in patients with myocardial infarction and normal heart function. The aim of this study is to determ...
Detailed Description
REDUCE-SWEDEHEART is designed as a registry-based, randomized, parallel, open-label, multicenter trial. Patients, day 1-7 after myocardial infarction, who have undergone a coronary angiography and wi...
Eligibility Criteria
Inclusion
- Age≥18 years.
- Day 1-7 after MI as defined by the universal definition of MI, type 1, included in the SWEDEHEART registry.
- Undergone coronary angiography during hospitalization.
- Obstructive coronary artery disease documented by coronary angiography, i.e. stenosis ≥ 50 %, FFR ≤ 0.80 or iFR ≤ 0.89 in any segment at any time point before randomization.
- Echocardiography performed after the MI showing a normal ejection fraction (EF≥50%).
- Written informed consent obtained.
Exclusion
- Any condition that may influence the patient's ability to comply with study protocol.
- Contraindications for beta-blockade
- Indication for beta-blockade other than as secondary prevention according to the treating physician.
Key Trial Info
Start Date :
September 11 2017
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2025
Estimated Enrollment :
5000 Patients enrolled
Trial Details
Trial ID
NCT03278509
Start Date
September 11 2017
End Date
December 31 2025
Last Update
March 5 2024
Active Locations (1)
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1
Danderyd Hospital, Cardiac Intensive Care
Danderyd, Stockholm County, Sweden, 182 88