Status:
COMPLETED
Ventilator Settings on Patients With Acute Brain Injury
Lead Sponsor:
University Hospital of North Norway
Collaborating Sponsors:
Cambridge University Hospitals NHS Foundation Trust
Hôpital de la Croix-Rousse
Conditions:
Acute Brain Injury
Ventilator-Induced Lung Injury
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The present study is an explorative analysis of the relationship between cerebral blood perfusion and oxygenation and lung mechanical variables at different ventilator settings. It is a safety study e...
Detailed Description
The primary goal is to carry out baseline measurements to enable conclusions concerning the safety of lung protective ventilator settings before extending the study to patients with more severe brain ...
Eligibility Criteria
Inclusion
- • Any tracheally intubated or tracheotomized adult patient with ABI with GCS\< 9 on controlled ventilation requiring continuous ICP measurement.
- Proxy informed consent from relatives.
Exclusion
- • ICP \> 22 mmHg before treatment of high ICP
- Acute respiratory failure defined as partial pressure of oxygen/ inspiratory oxygen fraction (PaO2/FiO2) ratio \< 40 kPa and Xray pathology
- History of pulmonary disese: Chronic respiratory failure diagnosis stage III and IV in the GOLD classification, pulmectomy, lobectomy or restrictive lung disease.
- Body mass index (BMI) \> 35.
- Known right or biventricular cardiac failure with cardiac index \< 2,5 L/min/m2 or ejection fracture \< 40 %.
- Refractory hypovolemia as diagnosed with pulse pressure variation \> 12 % with tidal volume 8 ml/predicted bodyweight (intubated on controlled ventilation) or passive leg rise test with \> 10 % increase in stroke volume measured by VTI echocardiography or PICCO.
- Medulla lesion that affect the autonomic nervous system.
- Patients who has undergone decompressive craniectomy.
Key Trial Info
Start Date :
June 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2022
Estimated Enrollment :
27 Patients enrolled
Trial Details
Trial ID
NCT03278769
Start Date
June 1 2019
End Date
January 1 2022
Last Update
May 23 2022
Active Locations (1)
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1
University Hospital North Norway
Tromsø, Troms, Norway, 9010