Status:
COMPLETED
Effects of Different Types of Carbohydrates in Snacks and Beverages on Glycemia, Insulinemia and Appetite.
Lead Sponsor:
JeyaKumar Henry
Collaborating Sponsors:
Tate and Lyle Ingredients France
Conditions:
Pre Diabetes
Obesity
Eligibility:
MALE
21-60 years
Phase:
NA
Brief Summary
The aim of the study is to describe the glycemic, insulinemic and appetitive responses to liquid and solid foods where either soluble fiber or maltodextrin are used as the carbohydrate substrate.
Detailed Description
Asia has the unenviable reputation as being the epicenter for type 2 diabetes. The Asian phenotype has been shown to be most susceptible to diabetes than Caucasians. More importantly, the transition f...
Eligibility Criteria
Inclusion
- Healthy Chinese male subjects aged between 21 and 60 years
- Either one of the three criteria:
- Normal weight (body mass index 18.5-22.9 kg/m2) and Fasting Blood Glucose 5.0-6.0mmol/L
- Overweight (body mass index 23.0 - 30.0 kg/m2) and Fasting Blood Glucose 5.0-6.0mmol/L
- Overweight (body mass index 23.0 - 30.0 kg/m2) and Fasting Blood Glucose \<5.0mmol/L
Exclusion
- Do smoke
- Have any metabolic diseases (such as diabetes, hypertension etc)
- Have known glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency)
- Have medical conditions and/or taking medications known to affect glycemia (glucocorticoids, thyroid hormones, thiazide diuretics)
- Have any major organ dysfunction (e.g. cardiovascular, respiratory, hepatic, renal, gastrointestinal) that may influence taste, olfaction, appetite, digestion, metabolism, absorption or elimination of test foods, nutraceutical or drug
- Consume fiber supplements or other supplements that is likely to interfere with study outcomes
- Have any severe food allergy (e.g. anaphylaxis to peanuts)
- Have any known allergies to any food components of the study protocol
- Have active Tuberculosis (TB) or currently receiving treatment for TB
- Have any known Chronic infection or known to suffer from or have previously suffered from or is a carrier of Hepatitis B Virus (HBV), Hepatitis C Virus (HCV), Human Immunodeficiency Virus (HIV)
- Is a study team member or an immediate family of any study team member. Immediate family member is defined as a spouse, parent, child, or sibling, whether biological or legally adopted.
- Is enrolled in a concurrent research study judged not to be scientifically or medically compatible with the study of the CNRC.
- Partake in sports at the competitive and/or endurance levels
- Intentionally restrict food intake
- Have poor veins impeding venous access
- Have any history of severe vasovagal syncope (blackouts or near faints) following blood draws
Key Trial Info
Start Date :
August 25 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 21 2020
Estimated Enrollment :
23 Patients enrolled
Trial Details
Trial ID
NCT03279107
Start Date
August 25 2017
End Date
July 21 2020
Last Update
August 20 2021
Active Locations (1)
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1
Clinical Nutrition Research Centre
Singapore, Singapore, 117599