Status:
COMPLETED
Effect of PEG, Bisacodyl and Prucalopride on Colonic Motility in Healthy Subjects
Lead Sponsor:
University Hospital, Gasthuisberg
Conditions:
Chronic Constipation
Eligibility:
All Genders
18-65 years
Phase:
PHASE4
Brief Summary
This study aim was to evaluate the effect of pharmacological treatments normally used to treat functional constipation and in particular PEG, bisacodyl and prucalopride on colonic motility as assessed...
Detailed Description
Rationale: Several treatments with different modes of action are currently available for chronic constipation. This study will investigate the effect of these different modes of actions of PEG 3350 + ...
Eligibility Criteria
Inclusion
- healthy male and non-pregnant, non-breastfeeding female participants, aged 18-65 years old at the time of consent
Exclusion
- use of medications within 48 h of dose initiation; structural or metabolic diseases that affect the gastrointestinal system and functional gastrointestinal disorders; previous abdominal surgery other than appendectomy, cholecystectomy, hysterectomy, or hernia repair; known illnesses such as diabetes, cardiovascular or lung disease; use of agents that influence bowel habit, i.e. anticholinergics (not including antihistamines with anticholinergic properties), spasmolytics and prokinetics in the 7 days before the study
Key Trial Info
Start Date :
December 3 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2016
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT03279341
Start Date
December 3 2012
End Date
March 1 2016
Last Update
September 12 2017
Active Locations (1)
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1
TARGID
Leuven, Belgium, 3000