Status:
COMPLETED
Vitamin D-related Genes and Metabolic Disorders
Lead Sponsor:
National Institute on Aging (NIA)
Conditions:
Metabolic Syndrome
Obesity
Eligibility:
All Genders
30-64 years
Brief Summary
The link between metabolic disturbances and vitamin D receptor (VDR) and MEGALIN (or LRP2) gene polymorphisms remains unclear, particularly among African-American adults. The associations of single nu...
Detailed Description
Adiposity, especially central adiposity, is a key component of the metabolic syndrome (MetS), which is accompanied by hyperglycemia, elevated blood pressure, lower HDL cholesterol and hypertriglycerid...
Eligibility Criteria
Inclusion
- 3,720 baseline participants (mean±SD age(y) of 48.3±9.4, 45.3% men, and 59.1% African-American),
- Genetic data were available on 1,024 African-American participants.
- Incomplete covariate data reduced the sample to n=769, while additional exclusions lead to a sample size ranging between 574 and 598 participants, with 539 having complete data on all baseline and follow-up outcome measures (cross-sectional part of the analysis).
- In the longitudinal analysis, metabolic disturbance-free at baseline participants were selected for each outcome. Sample sizes ranged from n=246 (central obesity-free) to n=466 (hyperglycemia-free).
- There were n=294 MetS-free individuals at baseline.
Exclusion
- Whites in HANDLS, since they did not have any genetic data collected.
- All African-Americans in HANDLS without genetic data collected.
- All African-Americans in HANDLS with genetic data collected, who had incomplete data on key outcome variables and/or basic covariates of interest.
Key Trial Info
Start Date :
August 18 2004
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 7 2013
Estimated Enrollment :
1021 Patients enrolled
Trial Details
Trial ID
NCT03279432
Start Date
August 18 2004
End Date
July 7 2013
Last Update
September 12 2017
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