Status:
UNKNOWN
Circulating Non-coding RNAs and Cardiovascular Outcomes in Patients With Dyslipidemia and Atherosclerosis
Lead Sponsor:
National Taiwan University Hospital
Conditions:
Cardiovascular Diseases
Eligibility:
All Genders
20+ years
Brief Summary
Cardiovascular diseases and stroke are the major causes of morbidity and death in Taiwan. There is a clear need to identify novel mediators of atherosclerosis in dyslipidemic patients to provide insig...
Detailed Description
Cardiovascular diseases and stroke are the major causes of morbidity and death in Taiwan. Patients with dyslipidemia are prone to atherosclerosis, which predispose to various cardiovascular pathology ...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Dyslipidemia: Total cholesterol (TC) \>200 mg/dL; LDL-C \> 130 mg/dL ; TG \> 200 mg/dL; male HDL-C \< 40 mg/dL, female HDL-C \< 50 mg/dL, or under lipid lowering therapy
- Atherosclerotic vascular disease:
- Coronary atherosclerosis as evidenced by cardiac catheterization examination, having history of myocardial infarction as evidenced by ECG or hospitalization, angina patient showing ischemic ECG changes or positive response to stress test;
- Cerebral vascular disease, cerebral infarction, intracerebral hemorrhage (excluding intracerebral hemorrhage associated with other diseases); transient ischemic attack (TIA) with carotid artery ultrasound confirming atheromatous change with more than 70% blockage;
- Peripheral atherosclerosis with symptoms of ischemia and confirmed by Doppler ultrasound or angiography in history.
- Control subjects: Age, gender-matched healthy adults without dyslipidemia and atherosclerotic diseases will be recruited as control subjects.
- Exclusion Criteria The main exclusion criteria will be hemodynamically significant valvular or congenital heart disease, life-threatening malignancy, treatment with immunosuppressive agents, or any condition or situation which, in the opinion of the investigator, might be not suitable for this registration.
Exclusion
Key Trial Info
Start Date :
June 1 2015
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2020
Estimated Enrollment :
1000 Patients enrolled
Trial Details
Trial ID
NCT03279770
Start Date
June 1 2015
End Date
December 1 2020
Last Update
September 15 2017
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
National Taiwan University Hospital
Taipei, Taiwan, 100