Status:
COMPLETED
Pranayama Practice on the Autonomic Nervous System
Lead Sponsor:
National University of Natural Medicine
Conditions:
Pranayama Effect on Autonomic Nervous System
Respiration Variability Effect on Nervous System
Eligibility:
All Genders
25-55 years
Phase:
EARLY_PHASE1
Brief Summary
The proposed study design will be a randomized, cross-over trial testing different pranayama breathing interventions. Participants (N=40) will perform each of the following five interventions in a ran...
Detailed Description
Healthy adult participants (N=40) will be recruited from the general population. Potential participants will contact a study phone line or email expressing their interest, and they will then be contac...
Eligibility Criteria
Inclusion
- Able to roll tongue into tube (queried over the phone and reassessed at visit 1)
- Age ≥ 25 and ≤ 55 (HRV and other ANS parameters change significantly during the aging process)
- BMI ≥ 18.5 and ≤ 34.9 (Body weight effects HRV and ANS parameters)
- Willing and able to give informed consent
- Able to follow protocol and attend visits
- Able to read and write English
- Able to abstain from over-the-counter painkillers like NSAIDs and allergy medications for 24 hours (Zyrtec and Claritin)
Exclusion
- A regular practice of yoga, meditation, and/or breathing more than once a week (Individuals that have conditioned their ANS through yoga, meditation, and breathing exercise may not respond to the breathing condition like the representative population)
- Formal (Yoga Alliance Sanctioned 200h or 500h course or other comparable ) training in yoga, Mindfulness-Based Stress Reduction, transcendental meditation, Qigong, Tai Chi, and/or other forms of meditation/consciousness expansion practices (Individuals that have conditioned their ANS through yoga, meditation, and breathing exercise may not respond to the breathing condition like the representative population)
- A recent cardiovascular event (e.g. myocardial infarction, stroke ≤ six months prior to screening visit), current coronary artery disease, angina, stage III or IV congestive heart failure, or stated history of coronary bypass surgery or heart stent placement
- Presence of a cardiac pacemaker
- History of cardiovascular disease, including heart arrhythmias and prehypertension (systolic BP \> 140 mmHg or diastolic BP \>90) or hypotension (systolic BP \< 90 mmHg or diastolic BP \<60)
- Taking prescription drugs that may interfere with heart, nervous, and respiratory rhythms, beta blockers, pain medications, SSRIs, anti-cholinergics, or anxiety medication
- Started or changed the dosage of supplements or medications within the last month
- Open skin rashes and sores that may interfere with placement of sensors
- History of emphysema, chronic bronchitis or bronchiectasis and/or asthma (with FEV1/FVC \< 80%) within in the last six months or taking medication to control asthma symptoms
- History of Diabetes type 1 or 2 (\> 5 year duration of type 2 diabetes or \> 10 years duration of type 1 diabetes (due to the potential for autonomic neuropathy)
- History of or current epilepsy or other seizure disorder(s)
- Current diagnosis of mental illness for which the participant is currently taking prescription medications
- Smoking of tobacco products in a the last 6 months
- Pregnant, nursing, or planning a pregnancy within the next 6 weeks (due to pregnancy-induced changes in HRV
- Presence of any unstable and/or significant medical disorder that would compromise the participant's safety to take part in the trial. Such disorders include any known event that will require beginning new medications and/or prevent adherence to the schedule of study activities over the following 6 weeks
- Chronic hyperventilation (Access by NQ during telephone screen)
Key Trial Info
Start Date :
August 15 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 21 2021
Estimated Enrollment :
25 Patients enrolled
Trial Details
Trial ID
NCT03280589
Start Date
August 15 2017
End Date
July 21 2021
Last Update
March 24 2023
Active Locations (1)
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1
National University of Natural Medicine
Portland, Oregon, United States, 97201