Status:

ACTIVE_NOT_RECRUITING

DANISH-CRT - Does Electric Targeted LV Lead Positioning Improve Outcome in Patients With Heart Failure and Prolonged QRS

Lead Sponsor:

Aarhus University Hospital

Collaborating Sponsors:

Aalborg University Hospital

Odense University Hospital

Conditions:

Heart Failure

Branch Block, Bundle

Eligibility:

All Genders

40+ years

Phase:

NA

Brief Summary

Heart failure is a leading cause of morbidity and mortality. Cardiac resynchronization therapy (CRT) is a well-established treatment for patients with symptomatic heart failure in spite of optimised m...

Eligibility Criteria

Inclusion

  • Heart Failure, NYHA II, III, outpatient IV
  • LVEF ≤35% measured by echocardiography
  • Optimal medical treatment for heart failure
  • Bundle Branch Block
  • Indication for primary CRT-D or CRT-P implantation or upgrade from RV pacing (pacemaker or ICD) to CRT-D or CRT-P
  • Ischemic heart disease (IHD) or non-IHD
  • Sinus rhythm or atrial fibrillation
  • Life expectancy \>2 years
  • Signed informed consent

Exclusion

  • NYHA class I
  • Acute mycardial infarction (AMI) within the latest 3 months
  • Coronary artery bypass graft (CABG) within the latest 3 months
  • Life expectancy \<2 years
  • Participation in another clinical trial of experimental treatment
  • Contraindication for establishing implantable device treatment
  • Previously implanted CRT system
  • Does not wish to participate

Key Trial Info

Start Date :

March 20 2018

Trial Type :

INTERVENTIONAL

Allocation :

ESTIMATED

End Date :

June 30 2026

Estimated Enrollment :

1000 Patients enrolled

Trial Details

Trial ID

NCT03280862

Start Date

March 20 2018

End Date

June 30 2026

Last Update

October 3 2025

Active Locations (5)

Enter a location and click search to find clinical trials sorted by distance.

Page 1 of 2 (5 locations)

1

Aalborg University Hospital

Aalborg, Denmark, 9000

2

Aarhus University Hospital

Aarhus, Denmark, 8200

3

Rigshospitalet

Copenhagen, Denmark, 2100

4

Gentofte University Hospital

Gentofte Municipality, Denmark, 2900