Status:
UNKNOWN
A Prospective Study of Evaluation of Minor Bleeding and Utility of Bleeding Criteria in Acute-on-chronic Liver Failure Patients in China
Lead Sponsor:
Nanfang Hospital, Southern Medical University
Conditions:
Liver Failure, Acute on Chronic
Hemostatic Disorder
Eligibility:
All Genders
18-80 years
Brief Summary
Ineffective hemostasis or a paradoxical prothrombotic state of Acute-on-chronic liver disease (ACLF) has been well established. However, the minor and major bleeding events has not been described yet....
Eligibility Criteria
Inclusion
- patient with previously or undiagnosed chronic liver disease/cirrhosis;
- serum bilirubin higher than 3 mg/dl (51 mmol/L) or ALT\>10ULN（male 300 U/L; female 200 U/L)
Exclusion
- those who had or been diagnosed hepatocellular carcinoma or other types of malignancies;
- pregnancy;
- obstructive biliary diseases or other disease lead to bilirubin evaluation;
- using steroid or immunosuppressant in 4 weeks;
- prior surgeries including splenectomy，subtotal splenectomy and disconnection，liver transplantation.
- combine with other disease lead to organ failure including heart failure (NYHA IV),respiratory failure（PaO2\<60mmHg),renal insufficiency(CKD 5) and conscious disturbance (GCS\<8)
Key Trial Info
Start Date :
April 16 2017
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 16 2017
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT03281252
Start Date
April 16 2017
End Date
September 16 2017
Last Update
September 13 2017
Active Locations (1)
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1
Nanfang Hospital
Guangzhou, Guangdong, China, 510515