Status:
COMPLETED
A Retrospective Multicenter Study of HBV-related Pre-acute-on-chronic Liver Failure in China
Lead Sponsor:
Nanfang Hospital, Southern Medical University
Conditions:
Liver Failure, Acute on Chronic
Liver Injury
Eligibility:
All Genders
18-80 years
Brief Summary
The definition and diagnostic criteria of Acute-on-chronic liver failure (ACLF) has been well established by EASL CANONIC study. However, patients with high risk to develop ACLF has not been determine...
Eligibility Criteria
Inclusion
- Chronic hepatitis B virus infection;
- Any of the followings: Alanine aminotransferase (ALT)≥3 upper limit of laboratory reference (ULN); Aspartate aminotransferase (AST)≥3 ULN; Serum bilirubin≥2 ULN; Acute decompensation (ascites, hepatic encephalopathy, variceal hemorrhage and/or bacterial infections)
Exclusion
- Previous decompensation;
- those who had hepatocellular carcinoma or other types of malignancies;
- those who combined with severe chronic extra-hepatic disease;
- pregnant;
- received liver transplantation or kidney transplantation before or after admission;
- readmission;
- death within 24 hours.
Key Trial Info
Start Date :
January 1 2012
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
February 28 2017
Estimated Enrollment :
1178 Patients enrolled
Trial Details
Trial ID
NCT03281265
Start Date
January 1 2012
End Date
February 28 2017
Last Update
January 23 2018
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