Status:
COMPLETED
Effects of Acute Intermittent Hypoxia on Sensory Function in Healthy Adults
Lead Sponsor:
University of Florida
Conditions:
Sensitivity
Eligibility:
All Genders
18-40 years
Phase:
NA
Brief Summary
Exposure to acute intermittent hypoxia (AIH) can facilitate of motor output but no studies of sensory effects has been reported.
Detailed Description
Despite the strong results of motor studies, the affects of AIH on sensory function has not been established. We will use a commercially-available hypoxicator that can be programmed to achieve a targe...
Eligibility Criteria
Inclusion
- 18 to 40 years of age
Exclusion
- Diagnosis of cardiovascular disease (Hypertension, arrhythmias, coronary artery disease, congenital and valvar heart diseases)
- Diagnosis of neuromuscular disease
- Diagnosis of any neurological disease
- Presence of concurrent medical illness including infection, fractures
- Diagnosis of obstructive sleep apnea
- Diagnosis of obstructive/restrictive lung disease
- Diagnosis of exercise induced asthma
- FEV1/FVC\<80% and/or FVC\<80% of predicted value indicating airway obstruction
- Subjects on prednisolone therapy or selective serotonin reuptake inhibitor (SSRI) therapy will be excluded from the study as these pharmacological agents are known to amplify the effects of IH\[22, 23\]
- Diagnosis of epilepsy or history of seizures and attention deficit disorders
- Pregnancy
- Diabetes
- History of coagulation disorders
- History of chronic pain
- Body mass index(BMI)\> 35kg/m2
- Subjects on prescription medicines such as beta blockers and other drugs that are prescribed in any of the exclusionary disorders listed above.
Key Trial Info
Start Date :
September 18 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 6 2020
Estimated Enrollment :
22 Patients enrolled
Trial Details
Trial ID
NCT03283072
Start Date
September 18 2017
End Date
July 6 2020
Last Update
August 21 2023
Active Locations (1)
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1
Unversity of Florida
Gainesville, Florida, United States, 32611