Status:
UNKNOWN
Prognostic Value of Carotid CEUS in Acute Ischemic Stroke Patients
Lead Sponsor:
Seoul National University Hospital
Collaborating Sponsors:
National Research Foundation of Korea
Seoul National University Bundang Hospital
Conditions:
Ultrasonography
Carotid Stenosis
Eligibility:
All Genders
20+ years
Brief Summary
Contrast-enhanced ultrasound(CEUS) of carotid artery plaque is a novel method that enabled direct visualization of neovessels in the vulnerable plaque. Plaque enhancement with CEUS showed correlation ...
Eligibility Criteria
Inclusion
- Patients older than 19 years presenting acute ischemic stroke.
- Compatible neurologic symptom within 14 days
- Compatible MRI finding (one or more positive DWI lesions in the territory of unilateral ICA: ACA or MCA territory) - interpretable MRI image obtained in SNUBH or outside hospital
- Etiology of acute ischemic stroke: except cardioembolic stroke (Atrial fibrillation) and other determined etiology
- Ipsilateral extracranial carotid artery stenosis on MRA (CE-MRA), CTA or Doppler ultrasound
Exclusion
- History of ipsilateral carotid stent or endarterectomy
- Carotid intervention during hospital stay
- Contraindication to ultrasound contrast agent (SonoVue) A. Right to left, bi-directional, or transient right to left cardiac shunts B. History of hypersensitivity reactions to sulfur hexafluoride lipid microsphere components or any ultrasound contrast agent C. Pregnant or lactating woman D. Unstable cardiopulmonary conditions (acute myocardial infarction, acute coronary artery syndromes, worsening congestive heart failure, or serious ventricular arrhythmias)
- Expected life span less than 12 months
Key Trial Info
Start Date :
August 9 2017
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 30 2020
Estimated Enrollment :
667 Patients enrolled
Trial Details
Trial ID
NCT03283306
Start Date
August 9 2017
End Date
September 30 2020
Last Update
September 14 2017
Active Locations (1)
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1
Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-do, South Korea, 13620