Status:
TERMINATED
Bedtime ACEIs/ARBs Versus Morning ACEIs/ARBs for Reverting Non-dipping Hypertension
Lead Sponsor:
Chinese University of Hong Kong
Conditions:
Hypertension
Non-Dipping
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
Background: Non-dipping (ND), defined as a \<10% decrease in blood pressure (BP) during sleep, is an independent significant predictor of cardiovascular outcome in hypertensive patients. A few anti-hy...
Eligibility Criteria
Inclusion
- Patients who are taking an ACEI or an ARB
- \>18 years of age
- Chinese and
- Received a diagnosis of primary HT.
Exclusion
- Severe HT as defined by a clinic systolic BP ≥180 mmHg and/or diastolic BP ≥ 110 mmHg
- allergic reaction or intolerance to the current ACEI or ARB
- unable to provide consent
- pregnancy
- night-time worker
- occupational drivers since patients will be asked not to move during BP measurements, which may induce potential danger in driving
- taking anti-coagulants to avoid causing bruises when using ABPM
- known atrial fibrillation since ABPM use has not been validated in this group
- known hyperkalemia
- ABPM discovered hypotension (mean SBP \< 100 and/or mean DBP \< 60) because these patients may need to stop their medications
- Reported sleep time of \<4 hours per night (at least seven readings are recommended during sleep for an ABPM recording to be valid, and a sleeping time \< 4 hours is unlikely to generate valid results).
Key Trial Info
Start Date :
December 1 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 31 2019
Estimated Enrollment :
4 Patients enrolled
Trial Details
Trial ID
NCT03284099
Start Date
December 1 2017
End Date
December 31 2019
Last Update
April 8 2020
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Lek Yuen Clinic
Hong Kong, Hong Kong