Status:
COMPLETED
Repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment of First Rank Symptoms (FRS) on Schizophrenia
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Conditions:
Schizophrenia Patients With First Rank Symptoms
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
First rank symptoms are core symptoms of schizophrenia. the investigators want to offer an integrative approach to better understanding of the mechanisms involved in the first rank symptoms and theref...
Detailed Description
Schizophrenia is a common psychiatric disorder that affects approximately 1% of the general population. This disease can be described in three dimensions: disorganization, delusions and negative signs...
Eligibility Criteria
Inclusion
- Suffering from schizophrenia (according to DSM IV-TR)
- Presenting FRS at least once a day despite well-conducted antipsychotic treatment, objectified by FRS subscore of the SAPS (items 2, 3 and items 15-19) with at least two FRS listed \> 1 of the corresponding item of the SAPS
- Being informed of the objectives and constraints of the study and signing the consent form or signing by the guardian
- Patient having had a preliminary clinical examination
Exclusion
- Left-lateralized
- Previously treated with rTMS in the previous 6 month,
- Contraindications of the rTMS practice: unstabilized epilepsy, presence of foreign eye metallic material, pacemaker, neurostimulator, cochlear implants and in general all medical equipment installed immovably, metal heart valve, vascular clips formerly located on cranial aneurysm
- Pregnancy or breastfeeding women
- hospitalization under constraint
- Subject already involved in another interventional clinical research evaluating schizophrenia treatment
- patient with severe drug use disorder (excluding coffee and tobacco) according to the DSM-5 criteria
Key Trial Info
Start Date :
August 3 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 3 2023
Estimated Enrollment :
31 Patients enrolled
Trial Details
Trial ID
NCT03284138
Start Date
August 3 2018
End Date
March 3 2023
Last Update
September 16 2025
Active Locations (1)
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1
Louis Mourier
Colombes, France, 92700