Status:
UNKNOWN
Relationship Between Neurological Disability and Visual Impairment in Patients With ALS or Friedreich's Ataxia
Lead Sponsor:
Jose Luis Urcelay Segura
Conditions:
Amyotrophic Lateral Sclerosis
Eligibility:
All Genders
18+ years
Brief Summary
The aim of this study is to obtain an early biomarker of amyotrophic lateral sclerosis and Friedreich's Ataxia which allows to diagnose the disease in an initial stage and to follow up the patient wit...
Detailed Description
All patients will be asked about their data and their general medical history, and will be underwent on one hand, a complete neurological examination including the degree of neurological impairment qu...
Eligibility Criteria
Inclusion
- Older than 18 years.
- Best corrected visual acuity more than 0.4 (20/50 Snellen = 0.4 logMAR = 65 ETDRS letters).
- Refractive defect less than 5 diopters of spherical equivalent and / or cylinder less than 2 diopters.
- Transparent optical media: Opacity of crystalline \<1 according to Lens Opacities Classification System (LOCS) III.
- Open anterior chamber angle assessed by gonioscopy with Goldmann lens (grade\> III).
- Availability and collaboration to carry out the tests of the exploratory protocol.
- Acceptance of informed consent.
Exclusion
- Previous intraocular surgeries of less than 6 months of evolution. Patients with refractive surgery using the LASIK or LASEK technique will not be excluded.
- Physical or mental difficulties to perform reliable and reproducible perimeters.
- Pathology and / or ocular malformations, angular or optic nerve anomalies.
- Any retinopathy or maculopathy.
- Intraocular pressure (IOP)\> 21 mmHg.
- Signal-to-noise ratio in OCT less than 5/10.
- Failure to meet any inclusion criteria.
- Mental retardation or any other limitation in obtaining informed consent.
Key Trial Info
Start Date :
July 1 2015
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
February 1 2020
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT03285204
Start Date
July 1 2015
End Date
February 1 2020
Last Update
February 26 2019
Active Locations (1)
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1
Pilar Rojas Lozano
Madrid, Spain, 28010