Status:
COMPLETED
Targeted OXYgen Therapy in Critical Illness
Lead Sponsor:
University College, London
Collaborating Sponsors:
Royal Free Hospital NHS Foundation Trust
University Hospital Southampton NHS Foundation Trust
Conditions:
Critical Illness
Respiratory Failure
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The investigators propose to conduct a feasibility, multi-centre, randomised controlled trial of targeted oxygen therapy in adult critically ill patients receiving mechanical ventilation via an endotr...
Detailed Description
The investigators aim is to determine whether revising standard targets for blood oxygen levels in patients requiring artificial ventilation on a critical care unit is feasible and whether this affect...
Eligibility Criteria
Inclusion
- Unplanned admission to a critical care unit
- 18 years of age and above (no upper age limit)
- Respiratory failure forms part of the admission diagnosis
- The patient is mechanically ventilated via an endotracheal tube
- The patient is expected to receive mechanical ventilation for \> 24 hours
Exclusion
- Admission following surgery (elective or unplanned)
- Those patients expected to die within 24 hours of admission to ICU \*
- Pregnant females
- Admission post-cardiac arrest
- Admission post trauma (including traumatic brain injury)
- Known sickle cell trait or disease
- Ongoing significant haemorrhage or profound anaemia
- Severe peripheral vascular disease
- Severe pulmonary hypertension
- Other medical conditions where mild hypoxaemia would be contra-indicated \*\*\*
- Patients participating in other interventional clinical trials
- As determined by the responsible clinical team \*\* As determined by the responsible clinical team and /or research team
Key Trial Info
Start Date :
January 15 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 15 2020
Estimated Enrollment :
34 Patients enrolled
Trial Details
Trial ID
NCT03287466
Start Date
January 15 2018
End Date
February 15 2020
Last Update
September 29 2021
Active Locations (1)
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1
Royal Free Hospital
London, United Kingdom, NW3 2QG