Status:
COMPLETED
Effect of Weight Loss and CPAP on OSA and Metabolic Profile Stratified by Craniofacial Phenotype
Lead Sponsor:
Chinese University of Hong Kong
Conditions:
Obstructive Sleep Apnea
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
Obstructive sleep apnea (OSA) is a common form of sleep-disordered breathing (SDB). Weight reduction has always been advocated in patients with OSA who are overweight and may lead to improvement in th...
Detailed Description
Obstructive sleep apnea (OSA) is a common form of sleep-disordered breathing (SDB). It causes sleep fragmentation, disabling daytime sleepiness, impaired cognitive function, poor quality of life and c...
Eligibility Criteria
Inclusion
- Patients diagnosed with moderate or severe obstructive sleep apnea ( apnea hypopnea index (AHI) ≥ 15); body mass index ≥25 kg/m2; age 18-70 years.
Exclusion
- Predominant central sleep apnea; conditions that will affect the level of hsCRP; unstable cardiovascular disease (e.g. recent unstable angina, myocardial infarction, stroke or transient ischemic attack within the previous 6 months or severe left ventricular failure; neuromuscular disease affecting or potentially affecting respiratory muscles; moderate to severe respiratory disease (i.e. breathlessness affecting activities of daily living) or documented hypoxemia or awake SaO2 \<92%); psychiatric disease that limits the ability to give informed consent or complete the study.
Key Trial Info
Start Date :
September 15 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 31 2020
Estimated Enrollment :
194 Patients enrolled
Trial Details
Trial ID
NCT03287973
Start Date
September 15 2017
End Date
August 31 2020
Last Update
February 15 2021
Active Locations (1)
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1
Chinese University of Hong
Hong Kong, Hong Kong